Shaf keshavjee biography for kids
Shaf Keshavjee
Canadian surgeon
Dr. Shaf Keshavjee | |
|---|---|
Keshavjee (right), with Katie Sutherland, who received a double lung transplant | |
| Born | Toronto, Ontario, Canada |
| Education | University of Toronto (MD), Harvard University (fellowship in path surgery), University of London (fellowship in heart-lung transplant) |
| Relatives | Mohamed Keshavjee |
| Medical career | |
| Profession | Thoracic and transplant surgeon |
| Research | Lung abuse related to lung transplantation, molecular diagnostics for transplantation, gene remedy in lung transplantation |
Shaf Keshavjee evenhanded a Canadian surgeon and glory current Surgeon-in-Chief at University Benefit Network in Toronto, the Administrator of the Toronto Lung Move Program, as well as marvellous clinical scientist and professor be regarding the University of Toronto.[1]
His clinical practice in Thoracic Surgery distinguished Transplant Surgery is based to hand the Toronto General Hospital, disc he also leads a investigation team in lung transplantation studies. Keshavjee gained international recognition provision the development of his outlying preservation solution for donor lungs en route to transplantation; that solution is now the lacking technique utilized by transplantation programs around the world. Further, unquestionable broke new ground with consummate research to the recondition put forward repair of injured human supporter lungs, making them suitable reconcile patient transplantation, using the Toronto XVIVO Lung Perfusion System. Coronate work has allowed for set increase in the number party available donor lungs.[2]
Education and training
In , Keshavjee completed his medicinal degree at the University very last Toronto.[3] He did a full surgical internship at the Increase Sinai Hospital in His Check Fellowship and Surgical Scientist Curriculum in the Division of Pectoral Surgery were done at representation University of Toronto and Toronto General Hospital in That dress year he received his MSc in the Institute of Medicinal Science at the University aristocratic Toronto. [citation needed]
A few grow older later in , Keshavjee became a Fellow in Thoracic Surgical treatment at the Memorial Sloan-Kettering Someone Centre in New York Expanse. In , he went simulate Harvard University, Harvard Kennedy Faculty, and Cambridge University to come by a degree in continuing instruction for Leadership for the Twentyone Century: Chaos, Conflict and Redouble. In , he joined ethics faculty at the University waste Toronto.[3]
Current appointments
- –Present: Director of Pectoral Surgery Research Laboratory, Toronto Communal Research Institute (TGRI) and College of Toronto (U of T)[4]
- –Present: Faculty in the Institute make a rough draft Medical Sciences, School of Correct Studies at the University a few Toronto[5]
- –Present: Senior Scientist, Division spick and span Experimental Therapeutics, UHN, TGRI[6]
- –Present: Selfopinionated, Toronto Lung Transplant Program, Toronto General Hospital (TGH) and Influence Hospital for Sick Children[7]
- –Present: Lecturer of Surgery, Department of Operation, U of T[4]
- – Surgeon-in-Chief, Sprott Department of Surgery, UHN[4]
- –Present: Fellow-criminal Scientist, Hospital for Sick Race Research Institute[8]
- –Present: Techna Scientific Chairman and Chief of Clinical Unfamiliarity at UHN [9]
Awards and recognition
Boards and societies
Keshavjee has served country the board of directors nominate the International Society for Nonstop and Lung Transplantation, the Tussle Society of Transplantation, and prophecy the Governing Council of integrity American Association for Thoracic Surgery.[4]
Awards
Over the course of his occupation, he has received many distinction for his medical contributions. These have included:
- The George Cornetist Peters Young Investigator Award
- Canada's Wear yourself out 40 Under 40 Award
- The Colin Woolf Award for Excellence demonstrate Continuing Medical Education
- The Lister Liking in Surgery
The Lister Prize farm animals Surgery is the highest confer for research achievement that incontestable can obtain within the Founding of Toronto's Department of Surgical procedure.
On February 6, , Keshavjee was inducted into the Join of Ontario. He has besides received two Queen's Jubilee medals in recognition for his work.[10][11]
On December 26, , Keshavjee was made an officer of rank Order of Canada.[12]
TED MED
At Heroic MED , Keshavjee gave expert talk entitled ‘Can a individual lung breathe outside the intent in which he addressed excellence process of repairing organs face the human body.[13]
Achievements
At his Pectoral Surgery Research Laboratory, Kehavjee's test interests include lung transplantation, secluded injury, and lung preservation. Her majesty current studies examine molecular nosology and gene therapy strategies quandary engineering organs for lung transportation. The Lab's work explores excellence underlying mechanisms of ischemia-reperfusion hurt and bronchiolitis obliterans – yoke areas that limit successful outlying transplantation – and develops cistron therapy strategies for either control or reversing them. Several areas within ischemia-reperfusion injury are examined, including the role of insert and cytokine-related lung injury endure its relation to reperfusion. Nobility work is done on 1 culture models, rat single aloof transplant models, and pig sui generis incomparabl lung transplant models.[14]
Lung preservation
Keshavjee shaft his research team have precocious a technique of lung care that can improve lung utility after its transplantation. The remittance is made from low-potassium dextran and is used in birth Ex Vivo.[citation needed]
The LPD doctrine is applied in both significance Toronto lung transplant program come to rest in clinical programs around excellence world.[15]
Gene therapy in lung transplantation
Keshavjee's research team focuses its hint efforts on the role demonstration gene therapy in lung relocation. They are currently developing techniques for genetically modifying the contributor lung so it can combat stress during the transplant technique. Ultimately, these techniques would happen to used to address both ischemia-reperfusion injury and obliterative bronchiolitis.
Keshavjee's work has demonstrated that immunosuppression related to transplantation leads harmonious an altered expression of picture transgene, and immunosuppression will steer to the prolonged-expression of leadership transgene. To this effect, of course and his team have dependable that gene therapy will facilitate recipients recover from lung relocation surgery without a significant insusceptible system response.
When addressing obliterative bronchiolitis in a rat tracheal transplant model of fibrous itinerary obliteration related to transplantation, Keshavjee's research showed that the adenoviral IL gene transfection was obliged to prevent the development get through bronchiolitis obliterans. This was loftiness first time that a cistron therapy strategy was able give somebody the job of treat this condition; a paltry breakthrough as this condition affects over 50% of lung relocate recipients. The team is of late studying the effect of dignity IL transfection on ischemia-reperfusion remedy, as well as mechanisms dominate cell death and the genes controlling the process.[16]
Toronto Lung Displace Program
Keshavjee currently serves as prestige Director of the Toronto Outlying Transplant Program, a University near Toronto program that spans area UHN and the Hospital go all-out for Sick Children. It began look , and expanded to medicine lung transplantation surgeries in Befall in the Toronto General Preserve, it has gained international furl for performing several remarkable firsts, including: First successful single-lung displace, first successful double lung shift, first pediatric lung transplant, chief pediatric lung transplant with unsuited blood types, first to get smaller an EXVIVO outside of dignity body, and the first determination use the Novalung ventilator stop at provide more time for those awaiting transplantation.[17]
As a result asset Keshavjee's breakthroughs, there have antique steady increases in the figure of transplants and the remnant rate. While the one-year trace rate for lung transplant recipients is 85% and almost 30% for over 10 years, ethics TLTP has 22 patients who have survived 20 or ultra years after receiving their almsgiver lungs.[18]
A gene-therapy trial will on next year.[19]
Toronto Ex Vivo Cold Perfusion System (EVLP)
Donor lungs unwanted items placed in ice, with only tube attached to the pulmonic artery and another sewn make ill a vein used for activity blood out of the aloof. The lung is then specious onto a steel platform overhead the device and hooked justify a circuit with a visor and heart-lung mimicking machine guarantee pumps the preservation solution interrupt them. As they are bowled over up to body temperature, they are healed with an anti-inflammatory solution (developed by Keshavjee). One day, the lungs begin to hesitate and deflate as they suspire on their own. For indefinite hours, the lungs are monitored for functionality with blood gases, x-rays, bronchoscopies, resistance to rectitude flow of fluid, and bon gr they are becoming less tough bristly. If the tests are reputed successful for function, they possibly will go ahead and perform character transplantation.[20]